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Also, 44% of patients treated with omeprazole did not respond to clopidogrel, whereas 23% of patients treated with pantoprazole were nonresponders.

Among 1198 patients with acute liver failure enrolled in a US prospective study between 1998 and 2007, 133 were attributed to drug induced liver injury, but none were linked to pantoprazole or other antiulcer medications).

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Pharmacodynamic parameters were also measured and demonstrated that the change in inhibition of platelet aggregation (induced by 5 µM ADP) was correlated with the change in the exposure to clopidogrel active metabolite.

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